Amino acid sequence and S-S bonds of Penicillium brevicompactum guanyl-specific ribonuclease
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چکیده
منابع مشابه
Nitrile bonds as infrared probes of electrostatics in ribonuclease S.
Three different nitrile-containing amino acids, p-cyanophenylalanine, m-cyanophenylalanine, and S-cyanohomocysteine, have been introduced near the active site of the semisynthetic enzyme ribonuclease S (RNase S) to serve as probes of electrostatic fields. Vibrational Stark spectra, measured directly on the probe-modified proteins, confirm the predominance of the linear Stark tuning rate in desc...
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Consden, R., Gordon, A. H. & Martin, A. J. P. (1944). Biochem. J. 38, 224. Consden, R., Gordon, A. H. & Martin, A. J. P. (1945). Biochem. J. 39, xlvi. Consden, R., Gordon, A. H. & Martin, A. J. P. (1946a). Biochem. J. 40, 33. Consden, R., Gordon, A. H. & Martin, A. J. P. (1946b). Biochem. J. 40, 580. Consden, R., Gordon, A. H., Martin, A. J. P. & Synge, R. L. M. (1947). Biochem. J. 41, 596. Mar...
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The copper binding properties of Penicillium brevicompactum biomass were influenced by growth phase of mycelium and concentration of copper in reaction mixtures. The efficiency of copper uptake increased with growth time and was largest at the mid-logarithmic growth phase. The time course of copper uptake was biphasic. Double reciprocal plots of absorption velocity of copper vs. copper concentr...
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A 70-residue analog of RNase S-protein was synthesized by the solid phase method. It was obtained by omitting the NH2 terminus from positions 21 to 25 and the segments 36 to 40, 58 to 73, 87 to 96, and 113 to 114. Four residues were inserted to link the ends formed by the deletions. Half-cystine residues that had not been part of the deletions were replaced by alanine or leucine residues. The s...
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Mycophenolic acid (MPA) is the active ingredient in the increasingly important immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the long history of MPA, the molecular basis for its biosynthesis has remained enigmatic. Here we report the discovery of a polyketide synthase (PKS), MpaC, which we successfully characterized and identified as responsible for MPA pro...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1984
ISSN: 0014-5793
DOI: 10.1016/0014-5793(84)81292-2